Additionally, E. coli infection also attenuated the expression of genes involved in fatty acid synthesis and utilization, such as stearoyl-CoA desaturase 1 (Scd1), long chain fatty acid-CoA ligase 1 (Acsl1), acyl-CoA thioesterase (Acot) 1 and 4, peroxisome proliferator-activated receptor (PPAR) γ coactivator 1-α and β (Ppargc1a and b), Forkhead box protein O1 (Foxo1), acetyl-CoA acyltransferase 1 (Acaa1b), and CCAAT/enhancer-binding protein (Cebp) α (Cebpa) in Mkp-1+/+ mice. Here, PPARGC1A is linked to escherichia coli infection.