Liver Cd36 mRNA levels were similar between control Mkp-1+/+ and Mkp-1−/− mice, and E. coli infection caused a significant increase in Cd36 mRNA levels in Mkp-1+/+ mice but had little effect on Cd36 mRNA levels in Mkp-1−/− mice. Here, DUSP1 is linked to escherichia coli infection.