CD8A and infection: This conclusion was challenged by demonstrating a perfect control of mCMV infection in mice long-term depleted of CD8+ T cells (likely also of CD8+ DCs) by anti-CD8 antibodies prior to infection [88] as well as in mice genetically deficient in CD8+ T cell differentiation due to a knockout of the gene encoding β2-microglobulin that is essential for correct folding of the epitope-presenting pMHC-I complex [89].