In the present study, DMC-CHC NPs demonstrated comparable cytotoxic effects compared to free DMC in A549 (Figure 1B), and decrease cisplatin-induced cell viability (Figure 4) through downregulation of TP and ERCC1-related pathways (Figure 4A,B) in NSCLC. This evidence concerns the gene ERCC1 and non-small cell lung carcinoma.