In vivo and in vitro studies of endoglin action mechanisms in HCC point out that in the liver, the effects of this protein are cell-specific, depending on the aetiology of HCC (e.g., higher expression in chronic hepatitis C), HCC differentiation, and stage of advancement of the pathological changes (e.g., higher expression in HCC with cirrhosis). Here, ENG is linked to hepatocellular carcinoma.