Triptolide-inhibited vascular endothelial growth factor (VEGF) induced angiogenesis in MDA-MB-231 and Hs578T breast cancer cells in vitro and decreased capillary density and cell proliferation in vivo in MDA-MB-231 cells injected into the mammary fat pad tumors of female nude mice [30]. The gene discussed is VEGFA; the disease is breast carcinoma.