AKT1 and non-small cell lung carcinoma: Interestingly, HPV16 oncoproteins seem to contribute to non-small cell lung cancer (NSCLC) progression by promoting hypoxia-inducible factor 1-alpha (HIF-1α)/VEGF-mediated tumor angiogenesis [122] and by enhancing EMT through the activation of PI3K/Akt/HIF-1α signaling [123].