TCF7 and glioblastoma: These data not only corroborate demonstrated convergence of the canonical Wnt/β-catenin and Stat3 signaling pathways [13,14,15], but also is indicative of the therapeutic efficacy of 4-AAQB in GBM cells through disruption of the CSC-associated oncogenic β-catenin/TCF-1/Stat3 signaling axis.