TCF7 and glioblastoma: Similarly, our immunoflourescence staining showed that compared with data from mice subjected to oral gavage of 4-AAQB (p.o), intraperitoneal injection of 4-AAQB (i.p) significantly decreased the nuclear and cytomenbranous expression of both TCF-1 and β-catenin, as well as inhibited their nuclear co-localization in the xenograft-derived GBM primary culture (Figure 7C).