UBE2E3 and familial pancreatic carcinoma: Furthermore, NF-κB induces gemcitabine resistance by interacting with novel regulators, Tripartite motif containing 31 (TRIM31) which is a newly identified E3 ubiquitin-protein ligase, markedly upregulated in pancreatic cancer cell lines and tissue, that correlates to aggressive behavior and poor prognosis in pancreatic cancer patients.