Furthermore, NF-κB induces gemcitabine resistance by interacting with novel regulators, Tripartite motif containing 31 (TRIM31) which is a newly identified E3 ubiquitin-protein ligase, markedly upregulated in pancreatic cancer cell lines and tissue, that correlates to aggressive behavior and poor prognosis in pancreatic cancer patients. This evidence concerns the gene NFKB1 and familial pancreatic carcinoma.