In an STZ-induced diabetic rat model, mangiferin ameliorated diabetic nephropathy by reducing oxidative stress and inhibit the expression of PKCs (PKCα, PKCβ and PKCε), MAPKs (p38, JNK and ERK1/2), NF-κβ and TGF-1β [121]. The gene discussed is NFKB1; the disease is diabetic kidney disease.