In vitro, recombinant IFN-α inhibits the infection by HTLV-1 of PBMCs, CBMCs (Cord Blood Mononuclear Cells), primary T-cells, and Jurkat T-cells [72,73], in a dose-dependent manner, notably through the expression of the ISG PKR (Protein Kinase R). Here, EIF2AK2 is linked to infection.