A common form of monogenic PD with dominant inheritance is caused by mutations in the gene for leucine-rich repeat kinase 2 (LRRK2) [8,9]; H-Synuclein (SNCA), which is a presynaptic neuronal protein, is linked genetically and neuropathologically to PD [10]; mutations in Parkin are the second most common known cause of PD [11]; mutations in DJ-1 and PTEN Kinase 1 (PINK1) can cause PD [11]; there is a significant inverse association of the ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with PD [12]; and variants in glucocerebrosidase (GBA) and SNCA influence PD risk [13]. The gene discussed is SNCA; the disease is Parkinson disease.