It is inferable that almost abolishment of PTEN in malignantly growing Nrf1α−/−-derived tumor cells results principally from an aberrant accumulation of Nrf2 protein, because rescue of PTEN expression occurs after Nrf2 is silenced, so that the existing Nrf1α−/−+siNrf2-derived tumor growth is dramatically repressed by Nrf2 knockdown. The gene discussed is PTEN; the disease is neoplasm.