Similar, but different, stress caused by liver-specific knockout of Nrf1−/−(ΔDBD) activates a subset of Nrf2-dependent ARE-battery genes in mice, but Nrf2 cannot still compensate for the loss of Nrf1’s function leading to NASH and HCC [27,28]. This evidence concerns the gene NFE2L2 and metabolic dysfunction-associated steatohepatitis.