NFE2L2 and neoplasm: This is evidenced by such observations that the malignant growth of Nrf1α−/− -derived tumor is almost prevented by silencing of Nrf2, and Nrf1α+/+-tumor growth is also repressed by the inactive Nrf2−/−ΔTA, but almost unaltered by constitutive activation of caNrf2ΔN in the presence of Nrf1α.