NFE2L2 and hepatocellular carcinoma: Since an unusual increase in Nrf2 protein is accompanied by relative higher levels of ROS in Nrf1α−/− cells (Figure 1F, Figure 2G and Figure S6), it is inferable that Nrf1α-deficient hepatoma cells are growing under severe redox stress conditions redefined at a new higher steady-state level that leads Nrf2 to become hyperactive.