NRF1 and neoplasm: Intriguingly, the vascularity of Nrf1α−/−+siNrf2-derived tumors seemed to be higher than that of Nrf1/2+/+-bearing tumors (Figure 6D), but such angiogenetic changes cannot serve to explain the observation that the Nrf1α−/−+siNrf2-tumor volumes and weights were significantly less than those obtained from the Nrf1/2+/+-tumors.