This is validated by further evidence revealing that, upon the presence of Nrf1 in caNrf2ΔN-derived tumor cells, its growth is almost unaffected by constitutive activation of Nrf2, as well as antioxidant and detoxifying genes, when compared with equivalents of wild-type Nrf1/2+/+-bearing tumor. The gene discussed is NRF1; the disease is neoplasm.