Herein, to elucidate what effects have been elicited by Nrf1α and Nrf2 on tumor repression or promotion, we further investigate distinct genotypic tumors derived from Nrf1/2+/+, Nrf1α−/−, Nrf1α−/−+siNrf2, Nrf2−/−ΔTA and caNrf2ΔN cells in xenograft mice. Here, NRF1 is linked to neoplasm.