For instance, when compared to those of Nrf1α−/− cells, silencing of Nrf2 caused 124 genes to be up-regulated, and still led 1338 genes to be down-regulated in Nrf1α−/−+siNrf2 cells (Figure 7A, last column), such that malignant growth of Nrf1α−/−-derived tumor was repressed by knockdown of Nrf2. The gene discussed is NFE2L2; the disease is neoplasm.