Significantly, the axiomatic rationale underlying distinct animal xenograft tumor phenotypes has also been unraveled by transcriptomic analysis of the genome-wide gene expression in Nrf1α−/−, Nrf1α−/−+siNrf2, Nrf2−/−ΔTA and caNrf2ΔN cell lines, when compared with wild-type Nrf1/2+/+. This evidence concerns the gene NFE2L2 and neoplasm.