Among Nrf1α-regulated genes, those encoding A2M, EPHA8, FBXO2, KCND1, SLC2A3, SORL1, OLIG2, and RAPGEF4 should be responsible for the nervous system, although it is unclear whether they are relevant to those phenotypes of Nrf1α−/− -leading neurodegenerative diseases as reported by [34,35]. Here, RAPGEF4 is linked to neurodegenerative disease.