DAPK1 and Parkinson disease: Although the Roco proteins, such as DAPK1 and a few from Dictyostelium and prokaryotes described above, have been studied for some time [1,8], they were not widely studied, and the features of Roc-COR had not been well characterized until two research groups linking mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2), a human Roco protein, with autosomal dominant Parkinson’s disease (PD) in 2004 [9,10].