MTOR and systemic lupus erythematosus: Interestingly, only one gene known to be involved in Mφ polarization had a z-score that contradicted this pattern: RICTOR, a relative of mTOR and a subunit of the mTORC2 complex, has been shown to suppress M1 polarization in mice yet is identified by IPA as an upstream regulator of CD14+ MC from active SLE patients.[55]