CD14 and systemic lupus erythematosus: As Mφ activation is known to encompass a spectrum of functional phenotypes controlled by finely-tuned molecular rheostats, we compared the fold change of DE genes that were commonly upregulated in CD14+ MC from both active and inactive SLE patients and found that common M1-associated genes (black wedges) were more highly upregulated in active patients whereas common M2-associated genes (white wedges) were more highly upregulated in inactive patients (Fig 1C).