Ki-67 (as a proliferative index) staining revealed significant changes in cell proliferation between the treated and control groups: the control group showed strikingly high Ki-67 expression, indicating growth and proliferation of tumor cells; a considerable decrease in Ki-67 expression was observed in all VGB4-treatedt groups but not in scr peptide treated group (P ≤ 0.05 for 0.25 mg/kg, and P ≤ 0.001 for 1, 2.5, 5 and 10 mg/kg) (Fig. 6E). The gene discussed is MKI67; the disease is neoplasm.