In the present study, given that signaling through both VEGFR1 and VEGFR2 is crucial for tumor angiogenesis, growth and metastasis20, a linear peptide was rationally designed from α2-β3 loop (loop1) and β5-β6 loop (loop3) of VEGF-B as well as β5-β6 loop (loop3) of VEGF-A, according to their complex with VEGFR1 D2 and VEGFR2 D2. This evidence concerns the gene KDR and neoplasm.