The lack of IL-2, its high affinity receptor chain IL-2Rα/CD25 or its transducing chain IL-2Rβ/CD12220, lead to the development of wasting autoimmunity as a result of the loss of stable Foxp3 expression5–7 and subsequent Foxp3+ Treg cells in the periphery21–23. Here, FOXP3 is linked to Autoimmunity.