ERBB4 and neoplasm: While several variants exhibited stable AFs consistent with truncal status in the tumor phylogeny (BRCA2 ~0.5; PTCH1 0.6–0.7; SAAL1 0.3–0.4; TP53 > 0.97), we observed an additional strong correlation between a mutation in MET and each of ERBB4 and LRP1B (MET vs. ERBB4: r = −0.65, p-val = 2.4e-13; MET vs. LRP1B: r = −0.78, pval = 2.2e-16).