Xie et al. found that ASPP2 overexpression suppressed methionine and choline-deficient (MCD) diet-induced autophagy, steatosis and apoptosis and reduced liver injury in a non-alcoholic fatty liver disease (NAFLD) mouse model, which indicated that ASPP2 may participate in hepatocyte apoptosis and liver injury11. The gene discussed is TP53BP2; the disease is metabolic dysfunction-associated steatotic liver disease.