During the metastatic cascade, cells in primary tumor adopt mesenchymal-like features and are then able to leave the primary tumor and colonize in other locations, such as in mouse breast or pancreatic cancer models where Snail1-positive or ‘EMTing’ cells are sometimes fully detached from epithelial islands while losing E-cad expression [51]. The gene discussed is SNAI1; the disease is pancreatic neoplasm.