IL6 and osteoarthritis: Studies have indicated that curcumin effectively reduced the inflammatory response of osteoarthritis by inhibiting the activation of NF‐κB and activator protein 1 (AP‐1) and the expression of inflammatory mediators, including cyclooxygenase‐2 (COX‐2), prostaglandin E2 (PGE2), nitric oxide synthase 1 (NO), interleukin 6 (IL‐6), and interleukin 8 (IL‐8)11, 12.