MMP3 and osteoarthritis: In summary, we validated the expression of MMP3 in osteoarthritis by western blot and quantitative real‐time polymerase chain reaction (qRT‐PCR), and examined the inhibitory effect of curcumin on MMP3. Experiments on cellular functions revealed that curcumin inhibited the proliferation of osteoarthritis synovial cells, promoted apoptosis, and relieved osteoarthritis inflammation by inhibiting the expression of MMP3.