Importantly, IL-2/CD40 reduced expression of a number of regulatory markers on young and elderly TDLN CD11c+ cells including: CD73 (Figure 6A), TGF-β (Figure 6A), CD39 (Supplementary Figure S6C) and IL-10 (Supplementary Figure S6C), relative to age-matched untreated tumor-bearing mice. The gene discussed is TGFB1; the disease is neoplasm.