We compared DCs and T cells from young (2–5 months; equivalent to 16–26 human years) (33) and elderly C57BL/6J mice (20–24 months; equivalent to 60–70 human years) (33, 34) in: (i) lymph nodes of healthy mice, and (ii) tumor-draining lymph nodes and tumors of mesothelioma-bearing mice, with and without IL-2/CD40 immunotherapy. Here, CD40 is linked to neoplasm.