Unexpectedly, IL-2/CD40 promoted a more regulatory phenotype in young tumor-associated CD8+ T cells, on account of increases in several regulatory markers, relative to PBS controls, specifically: CD39, A2AR, A2BR, ICOS, LAG-3, and PD-1 (Supplementary Figures S8B,C). The gene discussed is ENTPD1; the disease is neoplasm.