TNF and mesothelioma: However, mesothelioma induced age-related differences in TDLNs, including elevated proportions of IL-12+ and IFN-γ+ CD11c+ cells in elderly TDLNs (Supplementary Figure S1H); this is despite the observation that, regardless of age, mesothelioma reduced IL-12+, IFN-γ+, and TNF-α+ CD11c+ cell proportions in young and elderly TDLNs, compared to age-matched healthy LNs (Supplementary Figure S1H).