However, examination of DC subsets showed that mesothelioma significantly decreased cross presenting CD8α+CD11b− cDC (Figure 1B) and T helper 2 (Th2) cell-activating CD11b+CD8α−CD4− cDC proportions (Figure 1B) in TDLNs compared to LNs from age-matched healthy mice. The gene discussed is CD8A; the disease is mesothelioma.