IL4 and Alzheimer disease: As aforementioned, the importance of IL-4 and IL-13 in AD was highlighted by the newly developed and already licensed antibody dupilumab, which targets the IL-4-receptor alpha-chain of the heterodimeric IL-4 and IL-13 receptors, and, thus, blocks both IL-4 and IL-13 mediated effects, which has shown significant antipruritic and anti-eczematous effects in AD patients (64).