Additionally, the dying melanoma cells after M-ILP may express and/or release danger-associated molecular patterns (DAMPs) that potentiate immune responses as previously shown for anthracyclines, which reportedly trigger immunogenic cell death (ICD) by stimulating the DC engulfment of apoptotic bodies and by cross-presentation of antigens to cytotoxic CD8+ T cells (19). The gene discussed is CD8A; the disease is melanoma.