GLDC and cancer: Glycine has recently been reported as having a key role in cancer proliferation via cleavage of the amino acid by glycine decarboxylase and utilisation of the resulting one-carbon units to allow for increased mitochondrial activity [17, 18] and hence altered levels in cancer cells and an increase in A549 following treatment with miRNA mimics may reduce this metabolic pathway leading to elevations in uncatabolised glycine levels.