Out of the 183 genes associated with this pathway 51 (30.1%) were significantly modulated in DR cells including ICAM1, VEGFC, COL6A3 and COL1A. Interestingly, Hepatic Fibrosis was the most common pathway associated with both KDM1A and EWS/FLI knockdown in A673 cells [10] demonstrating that SP-2509 DR cells mimic cells with KDM1A/EWS-FLI loss. Here, ICAM1 is linked to Hepatic fibrosis.