TP53 and esophageal cancer: At the time of initiation of the • Pancho trial in 2007, the most important p53 databases reported a 40% prevalence for TP53 mutations in esophageal cancer (IARC TP53 Mutation Database, R12 release, Nov 07, http://www-p53.iarc.fr; UMD_TP53 Mutation Database, 2006, http://p53.free.fr) [18].