New biomarkers; neutrophil-to-lymphocyte count ratio (NLCR), neopterin and pro-adrenomedullin (pro-ADM) have been reported in recent studies as a potential biomarkers in the diagnosis and prognosis of sepsis.12-14 These biomarkers were evaluated separately in previous studies but there is no study comparing these markers with each other in the literature.15,16 We aimed to evaluate and compare the diagnostic value of NLCR, neopterin, pro-ADM and the other infection markers in patients with systemic inflammatory response syndrome (SIRS), sepsis and severe sepsis/septic shock in ICU. The gene discussed is ADM; the disease is infection.