Tumoral cDC1s were superior in stimulating naïve and previously activated CD8+ T-cells, beneficial for tumors with abundant Tregs, whereas cDC2s purified from tumor were more efficient in CD4+ T-cell stimulation and differentiation into Th17 cells, which was effective for tumors with abundant M2-oriented tumor-promoting tumor-associated macrophages (TAMs) (86, 87). The gene discussed is CD8A; the disease is neoplasm.