SIRT1 and type 2 diabetes mellitus: Identification of SIRT1 activators for T2DM treatment has become immediate areas of research focus, such as metformin, resveratrol, resveratrol derivatives (Resveratrol aliphatic acids, acetylated derivatives, 3,3′,4,4′,5,5′-hexahydroxystilbene) and polyphenols (quercetin, piceatannol, fisetin, pinosylvin, and butein) (145).