Tiotropium, one of the LAMAs with higher selectivity for M3 receptors, inhibited pulmonary neutrophilic inflammation and the release of leukotriene B4 (LTB4), interleukin-6 (IL-6), keratinocyte-derived chemokine(KC; IL-8 in humans), monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1alpha and -2 (MIP-1α and MIP-2), and tumor necrosis factor alpha (TNF-α) in a mouse COPD model induced by cigarette smoke (Wollin and Pieper, 2010). The gene discussed is TNF; the disease is chronic obstructive pulmonary disease.