Beneficial effects of FXR activation in patient with NAFLD include improved central insulin sensitivity in the liver and consequently increased glycogen synthesis, decrease in de novo lipogenesis in liver, improved insulin sensitivity adipose tissue (decreasing lipotoxic effects) and improved function of peroxisome proliferator-activated receptor-gamma (PPAR-γ) and PPAR-α, regulating fatty acid and glucose metabolism both in adipose tissue and liver (Fiorucci et al., 2007). Here, NR1H4 is linked to metabolic dysfunction-associated steatotic liver disease.