INS and type 2 diabetes mellitus: Subsequent “spill over” of free fatty acids from insulin resistant, dysfunctional adipose tissue initiates a phenomena of lipotoxicity caused by the accumulation of triacylglycerol-derived toxic metabolites in non-adipose tissues, inducing therefore inflammatory pathways, cellular dysfunction including insulin resistance, followed by impaired glucose control and type 2 diabetes (Mendez-Sanchez et al., 2018).