The diet supplementation with OCA (10 mg/kg/day) to fast food diet animal model of NASH, mimicking the metabolic syndrome features ablated micro RNA-21 (miR21) and activated PPAR-α that resulted in significant steatosis reduction, inflammation and lipo-apoptosis, unraveling restoration of miR21/PPAR-α axis in liver and muscle tissue by FXR and OCA (Rodrigues et al., 2017). The gene discussed is PPARA; the disease is metabolic dysfunction-associated steatohepatitis.