Recent evidence suggests that homeobox C6 (HOXC6) gene, a critical player in milk production and mammary gland development, has been found to be overexpressed in medulloblastomas [8] and osteosarcomas [9], as well as in variety of carcinomas including breast [10], lung [11] and prostate cancer s [12]. This evidence concerns the gene HOXC6 and osteosarcoma.