Quantitative data showed that densities of Ki67/IL-33 and Ki67/ST2 positive cells were increased in both ESCC and stromal cells as compared with controls (Ki67/IL-33 in ESCC vs. control: 17.0 (13.98–20.22) vs. 11.50 (10.28–14.92), P < 0.05; Ki67/IL-33 in stroma vs. control: 23.00 (18.09–26.51) vs. 17.50 (13.42–20.38), P < 0.05. This evidence concerns the gene IL33 and esophageal squamous cell carcinoma.