Regarding mechanisms of IL-33 promoting tumorigenesis, studies have suggested that that the IL-33 may regulate the expansion and function of different T cell subsets [15, 16], ILC2s [18] and nature killer (NK) cells [17, 18], stimulate the process of angiogenesis [36, 38–40], inhibit antitumor immunity [21, 24, 41] and promote tumor cell growth [25]. This evidence concerns the gene IL33 and neoplasm.