These data identified OPN, VIM, GPNMB and SPARC with the best diagnostic performance in discriminating between non-cirrhotic (F0-F3) and cirrhosis (F4) with AUROCs of OPN 0.78 [CI 0.62, 0.94], VIM 0.71 [CI 0.54, 0.87], GPNMB 0.73 [CI 0.56, 0.91] and SPARC 0.70 [CI 0.501, 0.90] (Table 2). This evidence concerns the gene SPP1 and Cirrhosis.