TNF and rheumatoid arthritis: Actually, the anti-TNF-α (inflixamab, adalimumab, etanercept, among others) and anti-IL-6 (tocilizumab, sarilumab, sirukumab, among others) biological therapies, which are effective RA treatments51,52, may be partially useful by targeting monocyte proinflammatory responses to circulating EVs.