ASCIZ and DYNLL1 have previously been shown to have equivalent effects on the development and expansion of Myc-driven cancers37,42, thus we monitored the growth of Cas9-expressing Brca1-/-p53-/- transplanted mouse cancer organoids43 transduced with control or Asciz-targeting gRNA (Supplementary Fig. 5f, g). Here, TP53 is linked to cancer.