Next, we determined the impact of the rs7665090G risk variant on NF-κB signaling in iPSC-derived astrocytes generated from fibroblasts of 12 MS patients and healthy controls, that are homozygous either for the risk (rs7665090GG) or protective variant (rs7665090AA) (Supplementary Fig. 2). The gene discussed is NFKB1; the disease is myeloid sarcoma.