INSR and carcinoma: Suppression of vascular INSR after angiostatic treatment was further confirmed in the mouse model of sunitinib-treated HT29 colorectal xenograft carcinomas grown subcutaneously in nude mice (Fig. 3d).34 Here, primers were used that selectively amplify mouse INSR transcripts in a background of human cDNA (Supplementary Table S1).