INSR and neoplasm: Transcriptome analysis of 226 CRC tissues and stratification of patients for higher and lower than average expression of INSR, demonstrated the negative relation with relapse-free survival of patients (Fig. 1d).26 As the expression of INSR is mainly present in the vasculature of tumours, it is suggested that high vascular INSR expression contributes to enhanced angiogenesis and increased tumour aggressiveness.