INS and cocaine dependence: In 2- vs. 6-month-old testes, the candidate target mRNAs were significantly involved in 11 pathways, which are shown in Figure 3 a: Hedgehog signaling pathway, vasopressin-regulated water reabsorption, WNT signaling pathway, cocaine addiction, microRNAs in cancer, gastric acid secretion, insulin secretion, melanogenesis, smooth muscle contraction, platelet activation, and glutamatergic synapse.