IGF1R and liver cancer: It was previously reported that miR-379 is a key miRNA that inhibits proliferation, invasion, and migration of tumor cells, and plays an important role in tumor occurrence and development; miR-379 can also inhibit proliferation, invasion, and migration of vascular smooth muscle cells by targeting IGF-1 and regulate breast and liver cancer processes by inhibiting the expression of Cyclin B1 and IGF-1R (Khan et al. 2013; Li et al. 2017a).