It was demonstrated that IFN-alpha and -gamma dramatically increase general SUMO1 and SUMO2/3 levels, in vitro as well as in vivo, through a microRNA-based mechanism (Sahin et al., 2014): this result prompted us to analyze the SUMO2 levels in Sca7266Q/5Q knock-in mice treated with IFN-beta compared with MSA-treated littermates. This evidence concerns the gene SUMO1 and multiple system atrophy.