We observed an activation of YAP/TAZ in melanoma CSCs treated with BRAF and/or MEK inhibitors, as documented by an increase of YAP/TAZ at the protein level in stable and primary cell lines (M14, Mel 66, Mel 29) (Fig. 4e-f), coupled with the increase of YAP/TAZ target genes such as ctgf, birc5, cyr61 and tead4 (Fig. 4g). The gene discussed is CCN1; the disease is melanoma.