HIF1A and pancreatic neoplasm: Treatment with Fuco-MnO2-NPs and PAH-MnO2-NPs, but not fucoidan alone, clearly suppressed hypoxia-induced HIF-1α expression (Figure 2c,d) or hypoxia-responsive luciferase activity (Figure 2e) in pancreatic cancer cells, indicating that the Fuco-MnO2-NPs alleviated the hypoxic condition via the generation of oxygen.