SOAT1 and myeloproliferative disorder: The demonstration that activating mutations in Jak produced neoplastic growth in flies, particularly in blood cell-like lineages [8,9,10,11], illustrated the striking similarity between the pathways across the animal kingdom, because, soon after, deregulated STAT function was linked to human hematopoietic malignancies and activating mutations in Jak were linked to leukemia and other myeloproliferative disorders [1,12,13,14].