Owing to technical advances, breast cancer is now classified on the basis of immunohistochemical markers and complementary DNA microarrays [4,5] into six different subtypes, namely, luminal A (ER+ and/or PR+ and HER2−), luminal B (ER+ and/or PR+ and HER2+), HER2 overexpressing (ER−, PR− and HER2+), normal-like, claudin-low and basal-like/TNBC (ER/PR/HER2 negative, cytokeratin 5/6+ and/or epidermal growth factor receptor+) (Figure 1) [3,5,6]. The gene discussed is ESR1; the disease is breast carcinoma.