Motiani and coworkers confirmed that SOCE in triple negative MDA-MB-231 breast cancer cells is entirely dependent on STIM1 and Orai1, while in MCF7, SOCE is mediated by STIM1, STIM2 and Orai3 (overexpressed in this cell line), thus reporting important phenotypic differences between both cell lines [83]. The gene discussed is ORAI3; the disease is breast cancer.