Consistent with this, the expression of a variety of Ca2+ channels is up-regulated in breast cancer cell lines and cancerous tissue, including Orai1, Orai3 and different TRP channels, such as TRPC6, TRPV6 and TRPM8, among others [49,50,51,52,53] (Table 1). This evidence concerns the gene ORAI1 and breast carcinoma.