In this study, bergamottin inhibited proliferation and induced apoptosis in human U266 MM cells through the downregulation of the signal transducer and activator of transcription 3 (STAT3) signaling pathway, which has been closely associated with tumorigenesis [70,71,72,73,74,75,76,77,78,79,80]. This evidence concerns the gene STAT3 and Miyoshi myopathy.