In cellular iron deficiency, IRPs bind to IREs at the 5’ untranslated region (UTR) of FPN1, FtH, FtL, delta-aminolevulinate synthase 1 (ALAS1), aconitase 2 (ACO2), hypoxia-inducible factor 2 (HIF2) mRNAs to mediate the degradation of the transcripts of the IREs to decrease iron storage and export [89]. Here, ACO2 is linked to Iron deficiency anemia.