Meanwhile, the presence of anti-SSA antibodies in both the 52 and 60 kD antigens has been correlated with progression to pSS.[19] In one UCTD patient cohort, those with anti-SSA and/or anti-SSB antibodies presented an SS-like disease.[19,20] In this patient, a high ANA titer and positive antibodies to Rho/SSA indicate progression to pSS, a well-defined CTD, in the future. This evidence concerns the gene SSB and synovial sarcoma.