SLC5A2 and Glycosuria: A previous study has suggested that homozygous or compound heterozygous mutations in the SLC5A2 gene can cause overt glucosuria.[7] Other research has also indicated that the heterozygous mutation of SLC5A2 might cause “mild” glucosuria.[10] However, increased glucose excretion was not observed in all individuals with similar or identical mutations, heterozygosity, in particular, indicating that other genetic or nongenetic factors are involved.[11]