The researcher presumed that the heterozygous mutation could be responsible for the latent hypofunction of NCCT causing acquired Gitelman syndrome.[22] We also reported the case of a pSS patient with an SLC12A3 heterozygous mutation presenting with acquired Gitelman syndrome.[23] Therefore, all of these case reports indicate that patients with autoimmune diseases, especially those on the spectrum of SS-like diseases, are more susceptible to renal tubular disorders, typically patients with heterozygous mutations in genes encoding renal tubular transporters. Here, SLC12A3 is linked to renal tubule disorder.