The efficacy of fish oil supplementation containing high omega-3 fatty acids on lipid metabolism is mediated through the reduction in very low-density lipoprotein (VLDL) production and suppression of VLDL and apolipoprotein B (apoB).[2–4] Lipid profile changes, including reduction in cholesterol and triglycerides, by omega-3 fatty acids have been reported in normal volunteers and patients with hyperglyceridemia.[5,6] Therefore, omega-3 fatty acids may be useful in patients with elevated triglyceride levels; however, the clinical role of omega-3 fatty acids is not well defined. This evidence concerns the gene APOB and hypertriglyceridemia.