MTHFR and ischemic stroke: The homozygous 677TT genotype of this mutation has been found to specify a variant enzyme with reduced activity and to be associated with elevated plasma levels of total homocysteine (tHcy), particularly in the setting of low folate levels, as compared to the wild-type (677CC) and heterozygous (677CT) genotypes.[25,26]MTHFR C677T polymorphism has been extensively investigated and considered to be a risk factor for various diseases, such as cancer, inflammatory bowel diseases, ischemic stroke, and coronary artery disease.[27–30]