For example, in 2010, Songserm et al performed a nested case–control study in the Thailand population and the result strongly suggest that polymorphisms in MTHFR genotypes act together with alcohol drinking and low folate intake to increase the risk of cholangiocarcinomas.[42] Di Daniele et al have explored the effects of Italian Mediterranean organic diet versus low-protein diet in nephropathic patients according to MTHFR genotypes. The gene discussed is MTHFR; the disease is cholangiocarcinoma.